Reprinted with permission from J Ap...

Reprinted with permission from J Appl Physiol. 2003; 95:677-684 ?© 2003 American Physiological Society.

Heart failure (HF) patients exhibit enhanced sympathetic tone, aberrant replys to blood pressure challenges, and sleep-related breathing disorders, suggesting that the syndrome is accompanied through central neural deficits. We assessed regional gray matter masss over the entire brain in nine HF patients (51 ?± 10 yr; left ventricular ejection fraction 027 ?± 006; six men) and 27 healthy superintends (46 ?± 12 yr; 22 men) using T1-weighted magnetic resonance imaging to evaluate potential neural damage. Regional books were evaluated by using voxel-based morphometry while controlling for age, sex and handedness. HF patients showed significant and largely lateralized gray matter los in autonomie and respiratoryrelated areas as well as regions not classically associated with of the like kind control, including the insula and basal ganglia, right cingulate gyrus, parahippocampal/fusiform gyrus, dorsal midbrain extending to the posterior and medial thalamus, ventral and superior lateral frontal cortex, bilateral cerebellar quadrangular lobule and right fastigial and neighboring nuclei, and bilateral discerning parietal and lateral parietal-occipital cortex. Areas of gray matter los may contribute to inappropriate cognitive, autonomie, and breathing regulation in HF

Copyright Cardiopulmonary Physical Therapy Journal Dec 2003

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