Purpose/Hypothesis: Despite pharmac...

Purpose/Hypothesis: Despite pharmacological advances, asthma continues to rise in incidence, severity and mortality. The decline in physical activity in industrialized societies, especially in children, may quick in emergencies as an environmental risk factor for the progressive prevalence and severity of this disease. Utilizing a juvenile mouse standard of atopic asthma, we ordealed the hypothesis that aerobic exercise training provides a glucocorticoid-mediated force which deters airway inflammation and disease progression. Number of Subjects: Thirty immunoglobulin E (IgE) respondent BALB/c mice (3-5 wks) mice were randomly prefered to 2 groups: asthma/sedentary and asthma/exercise. Materials/Methods: Mice were sensitized to chicken-egg albumin (ova) to mimic a chronic atopic asthmatic state. Mice received intraperitoneal injections (50 mg) upon Day 0, 14; 0.5% aerolized challenges for 30 min forward Days 21-25; and 0.5% booster 5 d/wk fur Iu min from head to foot the exercise protocol (wks 4-8) Mice who exercised did for a like reason 3x/wk for 4 wks al a moderate intensity (approx. 70% maximal oxygen consumption) upon a motorized treadmill. Results: Morphologically, exercised mice exhibited an attenuation of inflammatory confined apartment infiltration, mucus production, and epithelial hypertrophy as compared to sedentary mice. Also in comparison, exercised mice displayed 3-fold les bronchiolar lavage fluid (BALF) total lonely dwelling counts (p = 0.0.3) and les numbers of neutrophils, lymphocyte and eosinophils (p

A Pasta, L Schwiebert. Physiology and Biophysics, UAB, Birmingham, AL.

Copyright Cardiopulmonary Physical Therapy Journal Dec 2003

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